The National TB Conference 2021 will bring together stakeholders from within and outside Nigeria working to end Tuberculosis (TB) in the country. It will also provide a platform to deliberate on topical issues in TB control, and to foster and harness intersectoral and institutional collaboration to end TB in Nigeria. This conference will also focus on the magnitude and dimensions of the effects of the COVID-19 pandemic on TB control in Nigeria, and will provide an opportunity to share experiences and recommend strategies to address TB control during the current and future pandemics.